Luco is a surname. Notable people with the surname include:
Alberto Orrego Luco (1854–1931), Chilean landscape painter Ambrosio Montt Luco (1830–1899), Chilean politician and lawyer Ana Martinez de Luco (born 1960–61), Basque nun, sustainability advocate in New York City Ramón Barros Luco (1835–1919), President of Chile Ramón Briones Luco (1872–1949), Chilean politician
Footballers Horacio Díaz Luco (born 1943), played for clubs in Chile, Costa Rica and El Salvador Roberto Luco (footballer, born 1907), played for various South American clubs and for Chile Roberto Luco (footballer, born 1985), played for Santiago Wanderers (Chile), amongst others