Ortuño or Ortuno is a Spanish surname. Notable people with this surname include:
Alfredo Ortuño (born 1991), Spanish footballer Alicia Ortuño (born 1976), Spanish tennis player Antonio Ortuño (born 1976), Mexican novelist and short story writer Catalino Duarte Ortuño (born 1970), Mexican politician Fernando Ortuño (1945–2015), Spanish footballer Isabel Ortuño (born 1982), Spanish handballer Jesús Rodríguez Ortuño (born 1998), Spanish footballer Juanto Ortuño (born 1992), Spanish footballer Maria de los Angeles Rozalen Ortuno (born 1986), Spanish singer songwriter Rene Barrientos Ortuno (1919–1969), Bolivian military officer, president of Bolivia Sergio Ortuño (born 1999), Spanish footballer Teresa Ortuño Gurza (born 1957), Mexican politician Valeria Ortuño (born 1998), Mexican racewalker Washington Ortuño (1928–1973), Uruguayan footballer